Research workbench
Mouse MHC class I H-2KD with a MERS-cov-derived peptide 37-3
Analyse Mouse MHC class I H-2KD with a MERS-cov-derived peptide 37-3 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5GSB
- Type
- protein
- Length
- 382 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H-2 class I histocompatibility antigen, K-D alpha chain; Beta-2-microglobulin; MERS-cov…
- UniProt
- P01902, P61769
- Pockets
- 5 · best druggability 0.69
Structure
x-ray diffraction · 3 distinct chains · 19% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | H-2 class I histocompatibility antigen, K-D alpha chain | protein | 274 | 27% helix, 41% strand | P01902 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 49% strand | P61769 |
| C | MERS-cov peptide 37-3 | protein | 9 | 0% helix, 0% strand | — |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 639 | 0.69 | 0.77 | 62 | empty |
| 2 | 130 | 0.48 | 0.79 | 25 | empty |
| 3 | 81 | 0.39 | 0.78 | 16 | empty |
| 4 | 67 | 0.33 | 0.76 | 16 | empty |
| 5 | 55 | 0.29 | 0.75 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1339 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 1007 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5GSB · Mouse MHC class I H-2Kd with a MERS-CoV-derived peptide 37-3 · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P01902 · AlphaFold monomer V2.0 prediction for H-2 class I histocompatibility antigen, K-D alpha… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01902
- Every structure of UniProt P61769
- Elsewhere: RCSB PDB 5GSB · PDBe 5GSB · UniProt P01902 · UniProt P61769
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