Research workbench
Crystal structure of disulfide-bonded diabody
Analyse Crystal structure of disulfide-bonded diabody in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5GRX
- Type
- protein
- Length
- 460 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Diabody protein
- Pockets
- 3 · best druggability 0.46
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G | Diabody protein | protein | 229 | 8% helix, 49% strand | — |
| H | Diabody protein | protein | 231 | 8% helix, 49% strand | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.46 | 0.79 | 20 | empty |
| 2 | 158 | 0.40 | 0.73 | 29 | empty |
| 3 | 139 | 0.38 | 0.73 | 19 | empty |
Interfaces
1 interface between chains.
- G–H · 2055 Ų buried · 29 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 5GRX · Crystal structure of disulfide-bonded diabody · the same entry in another collection · chain G against G, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5GRX · PDBe 5GRX
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