Research workbench
Crystal structure of the C-terminal part of FUN30 ATPase domain
Analyse Crystal structure of the C-terminal part of FUN30 ATPase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5GN1
- Type
- protein
- Length
- 1,240 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP-dependent helicase FUN30
- EC
- 3.6.4.12
- UniProt
- P31380
- Pockets
- 19 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 55% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-dependent helicase FUN30 (EC 3.6.4.12) | protein | 309 | 54% helix, 11% strand | P31380 |
| B | ATP-dependent helicase FUN30 (EC 3.6.4.12) | protein | 309 | 55% helix, 11% strand | P31380 |
| C | ATP-dependent helicase FUN30 (EC 3.6.4.12) | protein | 310 | 54% helix, 11% strand | P31380 |
| D | ATP-dependent helicase FUN30 (EC 3.6.4.12) | protein | 312 | 55% helix, 11% strand | P31380 |
Pockets
19 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1015 | 0.76 | 0.79 | 84 | empty |
| 2 | 1101 | 0.72 | 0.76 | 80 | empty |
| 3 | 255 | 0.57 | 0.78 | 26 | empty |
| 4 | 298 | 0.55 | 0.76 | 30 | empty |
| 5 | 261 | 0.51 | 0.74 | 30 | empty |
Interfaces
6 interfaces between chains.
- A–D · 434 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 399 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 217 Ų buried · 6 hydrogen bonds · protein-protein
- B–D · 213 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 206 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 5GN1 · Crystal structure of the C-terminal part of Fun30 ATPase domain · the same entry in another collection · chain D against D, TM-score 1.00
- P31380 · AlphaFold monomer V2.0 prediction for ATP-dependent helicase FUN30 (P31380) · a predicted model of the same protein · chain C against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31380
- Elsewhere: RCSB PDB 5GN1 · PDBe 5GN1 · UniProt P31380
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