Research workbench
Crystal structure of a homing endonuclease, I-tnai
Analyse Crystal structure of a homing endonuclease, I-tnai in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5GKK
- Type
- protein
- Length
- 291 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative homing endonuclease
- UniProt
- Q70PR2
- Pockets
- 4 · best druggability 0.40
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative homing endonuclease | protein | 147 | 54% helix, 21% strand | Q70PR2 |
| B | Putative homing endonuclease | protein | 144 | 56% helix, 20% strand | Q70PR2 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 99 | 0.40 | 0.77 | 24 | empty |
| 2 | 123 | 0.39 | 0.75 | 19 | empty |
| 3 | 76 | 0.34 | 0.75 | 17 | empty |
| 4 | 85 | 0.34 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 905 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 5GKK · Crystal structure of a homing endonuclease, I-TnaI · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q70PR2
- Elsewhere: RCSB PDB 5GKK · PDBe 5GKK · UniProt Q70PR2
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