Research workbench
Cryo electron microscopy of a complex of tor and LST8
Analyse Cryo electron microscopy of a complex of tor and LST8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FVM
- Type
- protein
- Length
- 4,832 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase TOR2; Target of rapamycin complex subunit LST8
- UniProt
- A0A090BKR7, A0A090BJK6
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 61% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SERINE/THREONINE-protein kinase TOR2 | protein | 2117 | 69% helix, 2% strand | A0A090BKR7 |
| C, D | Target of rapamycin complex subunit LST8 | protein | 299 | 0% helix, 35% strand | A0A090BJK6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1073 | 0.82 | 0.83 | 167 | empty |
| 2 | 1102 | 0.80 | 0.81 | 127 | empty |
| 3 | 761 | 0.79 | 0.83 | 128 | empty |
| 4 | 657 | 0.77 | 0.83 | 103 | empty |
| 5 | 913 | 0.77 | 0.80 | 124 | empty |
Interfaces
3 interfaces between chains.
- A–B · 406 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 206 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 206 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5FVM · Cryo electron microscopy of a complex of Tor and Lst8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A090BKR7
- Every structure of UniProt A0A090BJK6
- Elsewhere: RCSB PDB 5FVM · PDBe 5FVM · UniProt A0A090BKR7 · UniProt A0A090BJK6
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