Research workbench

KPFLO11 presents a novel member of the FLO11 family with a unique recognition pattern for homophilic interactions

Analyse KPFLO11 presents a novel member of the FLO11 family with a unique recognition… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5FV6
Type: protein
Length: 353 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Flocculation protein FLO11
UniProt: C4R2D7
Ligands: NA
Pockets: 1 · best druggability 0.32

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Flocculation protein FLO11	protein	176	5% helix, 44% strand	C4R2D7
A	Flocculation protein FLO11	protein	177	5% helix, 45% strand	C4R2D7

Ligands and binding sites

NA · Sodium ion · metal · 3 copies · chains B, A
ACT · Acetate ion · additive · chains B
GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	90	0.32	0.73	16	empty

Interfaces

1 interface between chains.

B–A · 483 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

5FV6 · KpFlo11 presents a novel member of the Flo11 family with a unique recognition pattern for… · the same entry in another collection · chain B against B, TM-score 1.00
C4R2D7 · AlphaFold monomer V2.0 prediction for flocculation protein FLO11 (C4R2D7) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt C4R2D7
Elsewhere: RCSB PDB 5FV6 · PDBe 5FV6 · UniProt C4R2D7

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