Research workbench
Crystal structure of zebrafish protein arginine methyltransferase 2 catalytic domain with sah
Analyse Crystal structure of zebrafish protein arginine methyltransferase 2 catalytic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FUB
- Type
- protein
- Length
- 337 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein arginine methyltransferase 2
- EC
- 2.1.1.125
- UniProt
- A1L1Q4
- Ligands
- SAH, NA, CL
- Pockets
- 1 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 30% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein arginine methyltransferase 2 (EC 2.1.1.125) | protein | 337 | 30% helix, 34% strand | A1L1Q4 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
- NA · Sodium ion · metal · 2 copies · chains A
- CL · Chloride ion · ion · chains A
- EDO · 1,2-ethanediol · additive · 4 copies · chains A
- MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 335 | 0.78 | 0.89 | 49 | SAH, MES, EDO |
Compared structures
- 5FUB · Crystal Structure of zebrafish Protein Arginine Methyltransferase 2 catalytic domain with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A1L1Q4
- Elsewhere: RCSB PDB 5FUB · PDBe 5FUB · UniProt A1L1Q4
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