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RNA dependent RNA polymerase qde-1 from thielavia terrestris

Analyse RNA dependent RNA polymerase qde-1 from thielavia terrestris in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5FSW
Type: protein
Length: 3,690 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: RNA dependent RNA polymerase qde-1
UniProt: G2R911
Pockets: 20 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	RNA dependent RNA polymerase qde-1	protein	924	39% helix, 17% strand	G2R911
B, C, D	RNA dependent RNA polymerase qde-1	protein	922	39% helix, 15% strand	G2R911

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	963	0.81	0.82	69	empty
2	903	0.81	0.83	83	empty
3	787	0.71	0.77	83	empty
4	61	0.71	0.97	18	empty
5	743	0.70	0.77	65	empty

Interfaces

3 interfaces between chains.

A–B · 3824 Å² buried · 32 hydrogen bonds · protein-protein
C–D · 3630 Å² buried · 29 hydrogen bonds · protein-protein
A–D · 394 Å² buried · 3 hydrogen bonds · protein-protein

Compared structures

5FSW · RNA dependent RNA polymerase QDE-1 from Thielavia terrestris · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G2R911
Elsewhere: RCSB PDB 5FSW · PDBe 5FSW · UniProt G2R911

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