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Crystal structure of trypanosoma brucei macrodomain (crystal form 1)
Analyse Crystal structure of trypanosoma brucei macrodomain (crystal form 1) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FSU
- Type
- protein
- Length
- 475 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrodomain
- UniProt
- C9ZP98
- Pockets
- 4 · best druggability 0.56
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Macrodomain | protein | 235 | 42% helix, 15% strand | C9ZP98 |
| B | Macrodomain | protein | 240 | 40% helix, 15% strand | C9ZP98 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 370 | 0.56 | 0.75 | 40 | empty |
| 2 | 195 | 0.56 | 0.79 | 32 | empty |
| 3 | 144 | 0.52 | 0.80 | 22 | empty |
| 4 | 153 | 0.47 | 0.77 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 602 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 5FSU · Crystal structure of Trypanosoma brucei macrodomain (crystal form 1) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C9ZP98
- Elsewhere: RCSB PDB 5FSU · PDBe 5FSU · UniProt C9ZP98
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