Research workbench
Solution structure of intrastrand cisplatin-crosslinked DNA octamer D(CCTG*G*TCC):D(GGACCAGG), NMR, minimized average structure
Analyse Solution structure of intrastrand cisplatin-crosslinked DNA octamer… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1AU5
- Type
- DNA
- Length
- 16 nucleotides
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*CP*CP*TP*GP*GP*TP*CP*C)-3'); DNA (5'-D(*GP*GP*AP*CP*CP*AP*GP*G)-3')
- Ligands
- CPT
Structure
solution nmr · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA (5'-D(*CP*CP*TP*GP*GP*TP*CP*C)-3') | dna | 8 | — | — |
| B | DNA (5'-D(*GP*GP*AP*CP*CP*AP*GP*G)-3') | dna | 8 | — | — |
Ligands and binding sites
- CPT · Cisplatin · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 412 Ų buried · 48 hydrogen bonds · nucleic-nucleic
Compared structures
- 1AU5 · Solution structure of intrastrand cisplatin-crosslinked DNA octamer… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1AU5 · PDBe 1AU5
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