Research workbench
Structure of the PDS5-SCC1 complex and implications for cohesin function
Analyse Structure of the PDS5-SCC1 complex and implications for cohesin function in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FRS
- Type
- protein
- Length
- 694 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sister chromatid cohesion protein PDS5; Sister chromatid cohesion protein 1
- UniProt
- Q04264, Q12158
- Pockets
- 8 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sister chromatid cohesion protein PDS5 | protein | 677 | 66% helix, 0% strand | Q04264 |
| C | Sister chromatid cohesion protein 1 | protein | 17 | 0% helix, 6% strand | Q12158 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.77 | 0.94 | 27 | empty |
| 2 | 81 | 0.50 | 0.83 | 21 | empty |
| 3 | 54 | 0.41 | 0.82 | 15 | empty |
| 4 | 99 | 0.38 | 0.75 | 21 | empty |
| 5 | 53 | 0.34 | 0.78 | 13 | empty |
Interfaces
1 interface between chains.
- A–C · 913 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5FRS · Structure of the Pds5-Scc1 complex and implications for cohesin function · the same entry in another collection · chain A against A, TM-score 1.00
- Q04264 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein PDS5 (Q04264) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q12158 · AlphaFold monomer V2.0 prediction for sister chromatid cohesion protein 1 (Q12158) · a predicted model of the same protein · chain C against A, TM-score 0.23
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04264
- Every structure of UniProt Q12158
- Elsewhere: RCSB PDB 5FRS · PDBe 5FRS · UniProt Q04264 · UniProt Q12158
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.