Research workbench

Crystal structure of the cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with the adduct AMP-AN6426

Analyse Crystal structure of the cryptosporidium muris cytosolic leucyl-tRNA synthetase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5FOM
Type: protein
Length: 274 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Leucyl-tRNA synthetase
EC: 6.1.1.4
UniProt: B6AA20
Ligands: A2H, PO4
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Leucyl-tRNA synthetase (EC 6.1.1.4)	protein	274	34% helix, 26% strand	B6AA20

Ligands and binding sites

A2H · 4-chloro-3-aminomethyl-7-[ethoxy]-3H-benzo[c][1, 2]oxaborol-1-ol modified adenosine · ligand · chains A
PO4 · Phosphate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	358	0.73	0.84	34	A2H

Compared structures

5FOM · Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt B6AA20
Elsewhere: RCSB PDB 5FOM · PDBe 5FOM · UniProt B6AA20

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.