Research workbench
CRIFT52 N-terminal domain
Analyse CRIFT52 N-terminal domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5FMR
- Type
- protein
- Length
- 728 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intraflagellar transport protein component IFT52
- UniProt
- Q944U2
- Ligands
- SO4
- Pockets
- 8 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 25% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Intraflagellar transport protein component IFT52 | protein | 242 | 26% helix, 24% strand | Q944U2 |
| C | Intraflagellar transport protein component IFT52 | protein | 244 | 25% helix, 24% strand | Q944U2 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 4 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 714 | 0.64 | 0.73 | 75 | empty |
| 2 | 103 | 0.35 | 0.73 | 22 | empty |
| 3 | 76 | 0.34 | 0.75 | 14 | SO4 |
| 4 | 80 | 0.34 | 0.75 | 17 | SO4 |
| 5 | 77 | 0.34 | 0.75 | 13 | SO4 |
Interfaces
3 interfaces between chains.
- B–C · 688 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 679 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 677 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5FMR · crIFT52 N-terminal domain · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q944U2
- Elsewhere: RCSB PDB 5FMR · PDBe 5FMR · UniProt Q944U2
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