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Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza a virus polymerase PB2 subunit bound to M7GTP

Analyse Crystal structure of the mid, cap-binding, mid-link and 627 domains from avian… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5FMM
Type: protein
Length: 425 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Influenza a PB2 subunit
UniProt: Q6DNN3
Ligands: MGT
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Influenza a PB2 subunit	protein	425	38% helix, 26% strand	Q6DNN3

Ligands and binding sites

MGT · 7N-methyl-8-hydroguanosine-5'-triphosphate · ligand · chains A
FLC · Citrate anion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	460	0.72	0.82	47	MGT
2	537	0.67	0.78	65	empty
3	51	0.29	0.76	11	empty
4	52	0.26	0.74	17	empty

Compared structures

5FMM · crystal structure of the mid, cap-binding, mid-link and 627 domains from avian influenza… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6DNN3
Elsewhere: RCSB PDB 5FMM · PDBe 5FMM · UniProt Q6DNN3

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