Drosophila camkii-wt in complex with a fragment of the eag potassium channel and MG2+/ADP

Structure

x-ray diffraction · 2 distinct chains · 35% helix, 21% strand (DSSP).

Ligands and binding sites

• ADP · Adenosine-5'-diphosphate · ligand · chains A
• MG · Magnesium ion · metal · chains A
• GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 998 Ų buried · 21 hydrogen bonds · protein-protein

Compared structures

• 5FG8 · Drosophila CaMKII-wt in complex with a fragment of the Eag potassium channel and Mg2+/ADP · the same entry in another collection · chain A against A, TM-score 1.00
• Q00168 · AlphaFold monomer V2.0 prediction for CALCIUM/CALMODULIN-dependent protein kinase type II… · a predicted model of the same protein · chain A against A, TM-score 0.93
• Q02280 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel protein eag (Q02280) · a predicted model of the same protein · chain B against A, TM-score 0.33

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q00168
• Every structure of UniProt Q02280
• Elsewhere: RCSB PDB 5FG8 · PDBe 5FG8 · UniProt Q00168 · UniProt Q02280