Research workbench

Dsbc-dsbdalpha complex

Analyse Dsbc-dsbdalpha complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1JZD
Type: protein
Length: 551 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: THIOL:DISULFIDE interchange protein dsbc; THIOL:DISULFIDE interchange protein dsbd
UniProt: P21892, P36655
Pockets: 4 · best druggability 0.55

Structure

x-ray diffraction · 3 distinct chains · 32% helix, 31% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	THIOL:DISULFIDE interchange protein dsbc	protein	219	40% helix, 21% strand	P21892
B	THIOL:DISULFIDE interchange protein dsbc	protein	214	39% helix, 23% strand	P21892
C	THIOL:DISULFIDE interchange protein dsbd	protein	118	6% helix, 65% strand	P36655

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	290	0.55	0.76	49	empty
2	54	0.30	0.76	14	empty
3	53	0.27	0.74	13	empty
4	52	0.25	0.73	19	empty

Interfaces

3 interfaces between chains.

A–B · 953 Å² buried · 12 hydrogen bonds · protein-protein
B–C · 707 Å² buried · 12 hydrogen bonds · protein-protein
A–C · 362 Å² buried · 6 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1JZD · DsbC-DsbDalpha complex · the same entry in another collection · chain A against A, TM-score 1.00
P36655 · AlphaFold monomer V2.0 prediction for THIOL:DISULFIDE interchange protein dsbd (P36655) · a predicted model of the same protein · chain C against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P21892
Every structure of UniProt P36655
Elsewhere: RCSB PDB 1JZD · PDBe 1JZD · UniProt P21892 · UniProt P36655

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