Research workbench
An exquisitely specific PDZ/TARGET recognition revealed by the structure of inad PDZ3 in complex with TRP channel tail
Analyse An exquisitely specific PDZ/TARGET recognition revealed by the structure of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5F67
- Type
- protein
- Length
- 233 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inactivation-no-after-potential D protein; TRP C terminal tail
- UniProt
- Q24008
- Pockets
- 1 · best druggability 0.32
Structure
x-ray diffraction · 3 distinct chains · 17% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inactivation-no-after-potential D protein | protein | 98 | 18% helix, 39% strand | Q24008 |
| C, D | TRP C terminal tail | protein | 19 | 0% helix, 26% strand | — |
| B | Inactivation-no-after-potential D protein | protein | 97 | 19% helix, 39% strand | Q24008 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 61 | 0.32 | 0.76 | 17 | empty |
Interfaces
4 interfaces between chains.
- B–D · 640 Ų buried · 19 hydrogen bonds · protein-protein
- A–C · 635 Ų buried · 18 hydrogen bonds · protein-protein
- A–B · 216 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 98 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5F67 · An exquisitely specific PDZ/target recognition revealed by the structure of INAD PDZ3 in… · the same entry in another collection · chain A against A, TM-score 1.00
- Q24008 · AlphaFold monomer V2.0 prediction for inactivation-no-after-potential D protein (Q24008) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q24008
- Elsewhere: RCSB PDB 5F67 · PDBe 5F67 · UniProt Q24008
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