Research workbench

X-ray crystallographic structure of HTRAP1 N-terminal domain-apo

Analyse X-ray crystallographic structure of HTRAP1 N-terminal domain-apo in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5F3K
Type: protein
Length: 408 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Heat shock protein 75 kda, mitochondrial
UniProt: Q12931
Pockets: 4 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 44% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Heat shock protein 75 kda, mitochondrial	protein	205	43% helix, 22% strand	Q12931
B	Heat shock protein 75 kda, mitochondrial	protein	203	45% helix, 22% strand	Q12931

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	97	0.54	0.83	15	empty
2	110	0.49	0.80	16	empty
3	127	0.48	0.79	20	empty
4	97	0.42	0.78	17	empty

Interfaces

1 interface between chains.

A–B · 1713 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

5F3K · X-Ray Crystallographic Structure of hTrap1 N-terminal Domain-apo · the same entry in another collection · chain A against A, TM-score 1.00
Q12931 · AlphaFold monomer V2.0 prediction for heat shock protein 75 kda, mitochondrial (Q12931) · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12931
Elsewhere: RCSB PDB 5F3K · PDBe 5F3K · UniProt Q12931

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.