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Crystal structure of medicago truncatula histidinol-phosphate phosphatase (mthpp) in complex with L-histidinol

Analyse Crystal structure of medicago truncatula histidinol-phosphate phosphatase… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5EQ8
Type: protein
Length: 259 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inositol monophosphatase
UniProt: G7J7Q5
Ligands: HSO, CL
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 34% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Inositol monophosphatase	protein	259	34% helix, 26% strand	G7J7Q5

Ligands and binding sites

HSO · L-histidinol · ligand · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.45	0.77	25	HSO

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

5EQ8 · Crystal structure of Medicago truncatula Histidinol-Phosphate Phosphatase (MtHPP) in… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt G7J7Q5
Elsewhere: RCSB PDB 5EQ8 · PDBe 5EQ8 · UniProt G7J7Q5

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