Research workbench

Quorum-sensing signal integrator luxo - catalytic domain bound to cv- 133 inhibitor

Analyse Quorum-sensing signal integrator luxo - catalytic domain bound to cv- 133… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5EP3
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Putative repressor protein luxo
UniProt: Q1ZS18
Ligands: 5QT, SO4
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Putative repressor protein luxo	protein	253	47% helix, 14% strand	Q1ZS18

Ligands and binding sites

5QT · 2,2-dimethylpropyl 2-[(3-oxidanylidene-5-sulfanylidene-2~{H}-1,2,4-triazin-6-yl)amino]ethanoate · ligand · chains A
SO4 · Sulfate ion · ion · chains A
EPE · 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid · additive · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.43	0.76	22	5QT, SO4

Compared structures

5EP3 · Quorum-Sensing Signal Integrator LuxO - Catalytic Domain Bound to CV-133 Inhibitor · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q1ZS18
Elsewhere: RCSB PDB 5EP3 · PDBe 5EP3 · UniProt Q1ZS18

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.