Research workbench
Crystal structure of the SMU1-red complex (native) of caenorhabditis elegans.
Analyse Crystal structure of the SMU1-red complex (native) of caenorhabditis elegans. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5EN7
- Type
- protein
- Length
- 785 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Smu-1; Suppressor of mec and unc defects
- UniProt
- G5EEG7, Q9N4U5
- Pockets
- 11 · best druggability 0.45
Structure
x-ray diffraction · 7 distinct chains · 70% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Smu-1 | protein | 177 | 71% helix, 1% strand | G5EEG7 |
| B | Suppressor of mec and unc defects | protein | 16 | 69% helix, 0% strand | Q9N4U5 |
| D | Suppressor of mec and unc defects | protein | 15 | 67% helix, 0% strand | Q9N4U5 |
| E | Smu-1 | protein | 176 | 71% helix, 2% strand | G5EEG7 |
| F | Suppressor of mec and unc defects | protein | 19 | 53% helix, 0% strand | Q9N4U5 |
| G | Smu-1 | protein | 177 | 71% helix, 1% strand | G5EEG7 |
| H | Suppressor of mec and unc defects | protein | 28 | 71% helix, 0% strand | Q9N4U5 |
Pockets
11 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 137 | 0.45 | 0.76 | 19 | empty |
| 2 | 147 | 0.44 | 0.75 | 18 | empty |
| 3 | 138 | 0.40 | 0.74 | 27 | empty |
| 4 | 90 | 0.39 | 0.77 | 17 | empty |
| 5 | 94 | 0.38 | 0.76 | 15 | empty |
Interfaces
8 interfaces between chains.
- E–G · 1473 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 1410 Ų buried · 11 hydrogen bonds · protein-protein
- G–H · 700 Ų buried · 6 hydrogen bonds · protein-protein
- E–F · 616 Ų buried · 3 hydrogen bonds · protein-protein
- A–B · 602 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5EN7 · Crystal structure of the Smu1-RED complex (native) of Caenorhabditis elegans. · the same entry in another collection · chain H against H, TM-score 1.00
- G5EEG7 · AlphaFold monomer V2.0 prediction for smu-1 suppressor of mec-8 and unc-52 protein… · a predicted model of the same protein · chain E against A, TM-score 0.93
- Q9N4U5 · AlphaFold monomer V2.0 prediction for smu-2 suppressor of mec-8 and unc-52 protein… · a predicted model of the same protein · chain D against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt G5EEG7
- Every structure of UniProt Q9N4U5
- Elsewhere: RCSB PDB 5EN7 · PDBe 5EN7 · UniProt G5EEG7 · UniProt Q9N4U5
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