Research workbench
Structure of the star domain of T-star in complex with auuaaa RNA
Analyse Structure of the star domain of T-star in complex with auuaaa RNA in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5EMO
- Type
- protein + RNA
- Length
- 303 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kh domain-containing, RNA-binding, signal transduction- associated protein 3; RNA…
- UniProt
- O75525
- Pockets
- 3 · best druggability 0.34
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kh domain-containing, RNA-binding, signal transduction- associated protein 3 | protein | 144 | 48% helix, 15% strand | O75525 |
| B | Kh domain-containing, RNA-binding, signal transduction- associated protein 3 | protein | 147 | 44% helix, 15% strand | O75525 |
| E, F | RNA (5'-R(P*AP*UP*UP*AP*AP*A)-3') | rna | 6 | — | — |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 71 | 0.34 | 0.76 | 20 | empty |
| 2 | 64 | 0.31 | 0.75 | 17 | empty |
| 3 | 58 | 0.25 | 0.72 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2029 Ų buried · 23 hydrogen bonds · protein-protein
- B–E · 693 Ų buried · 11 hydrogen bonds · protein-nucleic
- A–F · 647 Ų buried · 8 hydrogen bonds · protein-nucleic
Compared structures
- 5EMO · Structure of the star domain of T-STAR in complex with AUUAAA RNA · the same entry in another collection · chain E against E, TM-score 1.00
- O75525 · AlphaFold monomer V2.0 prediction for kh domain-containing, RNA- binding, signal… · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75525
- Elsewhere: RCSB PDB 5EMO · PDBe 5EMO · UniProt O75525
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