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Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal LRRC3B PDZ binding motif

Analyse Crystal structure of the SNX27 PDZ domain bound to the phosphorylated… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5EMA
Type: protein
Length: 103 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorting nexin-27; Asp-asp-ile-sep-thr-val-val
UniProt: Q8K4V4

Structure

x-ray diffraction · 2 distinct chains · 13% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sorting nexin-27	protein	96	14% helix, 40% strand	Q8K4V4
B	Asp-asp-ile-sep-thr-val-val	protein	7	0% helix, 57% strand	—

Ligands and binding sites

GOL · Glycerol · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 536 Å² buried · 16 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

5EMA · Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal LRRC3B… · the same entry in another collection · chain A against A, TM-score 1.00
Q8K4V4 · AlphaFold monomer V2.0 prediction for sorting nexin-27 (Q8K4V4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8K4V4
Elsewhere: RCSB PDB 5EMA · PDBe 5EMA · UniProt Q8K4V4

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