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Three-dimensional structure of an immunoglobulin light chain dimer acting as a lethal amyloid precursor

Analyse Three-dimensional structure of an immunoglobulin light chain dimer acting as a… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1JVK
Type: protein
Length: 431 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Immunoglobulin lambda light chain
UniProt: Q6PJG0
Pockets: 5 · best druggability 0.66

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Immunoglobulin lambda light chain	protein	216	6% helix, 49% strand	Q6PJG0
B	Immunoglobulin lambda light chain	protein	215	7% helix, 49% strand	Q6PJG0

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	276	0.66	0.82	37	empty
2	544	0.62	0.75	54	empty
3	183	0.46	0.75	28	empty
4	62	0.34	0.77	19	empty
5	81	0.32	0.74	19	empty

Interfaces

1 interface between chains.

A–B · 1810 Å² buried · 20 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 2 modified (disulfide, cyclization).

Compared structures

1JVK · Three-dimensional structure of an immunoglobulin light chain dimer acting as a lethal… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6PJG0
Elsewhere: RCSB PDB 1JVK · PDBe 1JVK · UniProt Q6PJG0

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