Research workbench
Crystal structure of the NUP98 C-terminal domain bound to nanobody TP377
Analyse Crystal structure of the NUP98 C-terminal domain bound to nanobody TP377 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5E0Q
- Type
- protein
- Length
- 278 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anti-NUP98 nanobody TP377; Nuclear pore complex protein NUP98-NUP96
- UniProt
- J7I6Y1
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anti-NUP98 nanobody TP377 | protein | 126 | 5% helix, 49% strand | — |
| B | Nuclear pore complex protein NUP98-NUP96 | protein | 152 | 17% helix, 34% strand | J7I6Y1 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.42 | 0.78 | 20 | empty |
| 2 | 69 | 0.32 | 0.75 | 19 | empty |
Interfaces
1 interface between chains.
- A–B · 779 Ų buried · 21 hydrogen bonds · protein-protein
Compared structures
- 5E0Q · Crystal structure of the Nup98 C-terminal domain bound to nanobody TP377 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt J7I6Y1
- Elsewhere: RCSB PDB 5E0Q · PDBe 5E0Q · UniProt J7I6Y1
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