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Crystal structure of cytochrome P450 2B37 from desert woodrat in complex with 4-(4-CHLOROPHENYL)IMIDAZOLE

Analyse Crystal structure of cytochrome P450 2B37 from desert woodrat in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5E0E
Type: protein
Length: 463 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450 family 2 subfamily B
UniProt: J9JD75
Ligands: CPZ, HEM
Pockets: 3 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450 family 2 subfamily B	protein	463	48% helix, 10% strand	J9JD75

Ligands and binding sites

CPZ · 4-(4-chlorophenyl)imidazole · ligand · 3 copies · chains A
HEM · Protoporphyrin IX containing Fe · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1121	0.85	0.86	99	HEM, CPZ
2	69	0.33	0.75	15	empty
3	50	0.31	0.77	13	empty

Compared structures

5E0E · Crystal Structure of Cytochrome P450 2B37 from Desert Woodrat in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt J9JD75
Elsewhere: RCSB PDB 5E0E · PDBe 5E0E · UniProt J9JD75

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