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Crystal structure of the protein human CEACAM1

Analyse Crystal structure of the protein human CEACAM1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5DZL
Type: protein
Length: 429 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carcinoembryonic antigen-related cell adhesion molecule 1
UniProt: P13688
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 50% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Carcinoembryonic antigen-related cell adhesion molecule 1	protein	107	6% helix, 51% strand	P13688
D	Carcinoembryonic antigen-related cell adhesion molecule 1	protein	108	0% helix, 48% strand	P13688

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1156	0.75	0.78	69	empty
2	167	0.49	0.77	29	empty
3	86	0.36	0.76	20	empty

Interfaces

5 interfaces between chains.

A–B · 859 Å² buried · 14 hydrogen bonds · protein-protein
C–D · 843 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 257 Å² buried · 3 hydrogen bonds · protein-protein
B–D · 238 Å² buried · 1 hydrogen bond · protein-protein
B–C · 114 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

5DZL · Crystal structure of the protein human CEACAM1 · the same entry in another collection · chain D against D, TM-score 1.00
P13688 · AlphaFold monomer V2.0 prediction for carcinoembryonic antigen- related cell adhesion… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13688
Elsewhere: RCSB PDB 5DZL · PDBe 5DZL · UniProt P13688

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