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Mus musculus A20 otu domain

Analyse Mus musculus A20 otu domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5DQ6
Type: protein
Length: 666 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tumor necrosis factor alpha-induced protein 3
EC: 3.4.19.12, 6.3.2.-
UniProt: Q60769
Pockets: 11 · best druggability 0.79

Structure

x-ray diffraction · 2 distinct chains · 34% helix, 15% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tumor necrosis factor alpha-induced protein 3 (EC 3.4.19.12, 6.3.2.-)	protein	336	34% helix, 15% strand	Q60769
B	Tumor necrosis factor alpha-induced protein 3 (EC 3.4.19.12, 6.3.2.-)	protein	330	33% helix, 15% strand	Q60769

Pockets

11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1134	0.79	0.80	95	empty
2	69	0.73	0.97	19	empty
3	69	0.71	0.95	22	empty
4	237	0.58	0.79	30	empty
5	146	0.47	0.77	18	empty

Interfaces

1 interface between chains.

A–B · 587 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

5DQ6 · Mus musculus A20 OTU domain · the same entry in another collection · chain A against A, TM-score 1.00
Q60769 · AlphaFold monomer V2.0 prediction for tumor necrosis factor alpha- induced protein 3… · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q60769
Elsewhere: RCSB PDB 5DQ6 · PDBe 5DQ6 · UniProt Q60769

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