Research workbench
Crystal structure of C-terminal domain of mouse ERF1 in complex with RNase H domain of rt of moloney murine leukemia virus
Analyse Crystal structure of C-terminal domain of mouse ERF1 in complex with RNase H… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5DMR
- Type
- protein
- Length
- 260 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Reverse TRANSCRIPTASE/RIBONUCLEASE H P80; Eukaryotic peptide chain release factor subunit…
- EC
- 3.1.26.4
- UniProt
- P03355, Q8BWY3
- Pockets
- 3 · best druggability 0.51
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Reverse TRANSCRIPTASE/RIBONUCLEASE H P80 (EC 3.1.26.4) | protein | 139 | 37% helix, 24% strand | P03355 |
| B | Eukaryotic peptide chain release factor subunit 1 | protein | 121 | 36% helix, 31% strand | Q8BWY3 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 218 | 0.51 | 0.77 | 25 | empty |
| 2 | 220 | 0.51 | 0.76 | 28 | empty |
| 3 | 56 | 0.36 | 0.79 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 676 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 5DMR · Crystal Structure of C-terminal domain of mouse eRF1 in complex with RNase H domain of RT… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8BWY3 · AlphaFold monomer V2.0 prediction for eukaryotic peptide chain release factor subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Every structure of UniProt Q8BWY3
- Elsewhere: RCSB PDB 5DMR · PDBe 5DMR · UniProt P03355 · UniProt Q8BWY3
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.