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Crystal structure analysis of VP39-F180W mutant and M7GPPPG complex

Analyse Crystal structure analysis of VP39-F180W mutant and M7GPPPG complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1JTF
Type: protein
Length: 291 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: VP39
EC: 2.7.7.19
UniProt: P07617
Ligands: SAH, M7G
Pockets: 4 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	VP39 (EC 2.7.7.19)	protein	291	41% helix, 18% strand	P07617

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · chains A
M7G · 7N-methyl-8-hydroguanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	230	0.51	0.76	43	SAH, M7G
2	73	0.35	0.77	16	empty
3	54	0.33	0.77	15	SAH
4	58	0.30	0.75	13	empty

Compared structures

1JTF · Crystal Structure Analysis of VP39-F180W mutant and m7GpppG complex · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07617
Elsewhere: RCSB PDB 1JTF · PDBe 1JTF · UniProt P07617

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