Research workbench
Human acidic fibroblast growth factor. 141 amino acid form with amino histidine tag and leu 73 replaced by val (L73V)
Analyse Human acidic fibroblast growth factor. 141 amino acid form with amino histidine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JT3
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Acidic fibroblast growth factor
- UniProt
- P05230
- Ligands
- SO4
- Pockets
- 2 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Acidic fibroblast growth factor | protein | 143 | 6% helix, 39% strand | P05230 |
| B | Acidic fibroblast growth factor | protein | 142 | 6% helix, 38% strand | P05230 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 123 | 0.42 | 0.76 | 20 | empty |
| 2 | 55 | 0.24 | 0.72 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 427 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1JT3 · Human Acidic Fibroblast Growth Factor. 141 Amino Acid Form with Amino Histidine Tag AND… · the same entry in another collection · chain A against A, TM-score 1.00
- P05230 · AlphaFold monomer V2.0 prediction for fibroblast growth factor 1 (P05230) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P05230
- Elsewhere: RCSB PDB 1JT3 · PDBe 1JT3 · UniProt P05230
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