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Crystal structure of gab reveals oxidoreductase fold

Analyse Crystal structure of gab reveals oxidoreductase fold in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1JR7
Type: protein
Length: 306 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hypothetical 37.4 kda protein in iley-gabd intergenic region
UniProt: P76621
Ligands: FE2
Pockets: 2 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hypothetical 37.4 kda protein in iley-gabd intergenic region	protein	306	28% helix, 28% strand	P76621

Ligands and binding sites

FE2 · Fe (II) ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	695	0.75	0.81	59	FE2
2	111	0.36	0.73	17	empty

Compared structures

1JR7 · Crystal structure of gab reveals oxidoreductase fold · the same entry in another collection · chain A against A, TM-score 1.00
P76621 · AlphaFold monomer V2.0 prediction for glutarate 2-hydroxylase (P76621) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P76621
Elsewhere: RCSB PDB 1JR7 · PDBe 1JR7 · UniProt P76621

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