Research workbench
Crystal structure of human SART3/TIP110 half-a tpr (hat) domain
Analyse Crystal structure of human SART3/TIP110 half-a tpr (hat) domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CTQ
- Type
- protein
- Length
- 2,005 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Squamous cell carcinoma antigen recognized by T-cells 3
- UniProt
- Q15020
- Pockets
- 20 · best druggability 0.77
Structure
x-ray diffraction · 4 distinct chains · 77% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 518 | 78% helix, 0% strand | Q15020 |
| B | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 490 | 76% helix, 0% strand | Q15020 |
| C | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 495 | 77% helix, 0% strand | Q15020 |
| D | Squamous cell carcinoma antigen recognized by T-cells 3 | protein | 502 | 77% helix, 0% strand | Q15020 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1165 | 0.77 | 0.79 | 90 | empty |
| 2 | 967 | 0.75 | 0.78 | 98 | empty |
| 3 | 1055 | 0.74 | 0.77 | 95 | empty |
| 4 | 422 | 0.64 | 0.78 | 37 | empty |
| 5 | 252 | 0.57 | 0.78 | 32 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1545 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 1496 Ų buried · 31 hydrogen bonds · protein-protein
- B–C · 629 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 453 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5CTQ · Crystal structure of human SART3/TIP110 half-a TPR (HAT) domain · the same entry in another collection · chain D against D, TM-score 1.00
- Q15020 · AlphaFold monomer V2.0 prediction for squamous cell carcinoma antigen recognized by… · a predicted model of the same protein · chain D against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15020
- Elsewhere: RCSB PDB 5CTQ · PDBe 5CTQ · UniProt Q15020
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