Research workbench
E. COLI mazf mutant E24A in complex with maze residues 68-82 form I
Analyse E. COLI mazf mutant E24A in complex with maze residues 68-82 form I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CQX
- Type
- protein
- Length
- 237 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endoribonuclease mazf; Antitoxin maze
- EC
- 3.1.27.-
- UniProt
- P0AE70, P0AE72
- Pockets
- 3 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endoribonuclease mazf (EC 3.1.27.-) | protein | 106 | 31% helix, 29% strand | P0AE70 |
| B | Endoribonuclease mazf (EC 3.1.27.-) | protein | 116 | 22% helix, 28% strand | P0AE70 |
| C | Antitoxin maze | protein | 15 | 0% helix, 0% strand | P0AE72 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 257 | 0.68 | 0.84 | 40 | empty |
| 2 | 175 | 0.54 | 0.79 | 25 | empty |
| 3 | 84 | 0.41 | 0.78 | 21 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1351 Ų buried · 9 hydrogen bonds · protein-protein
- A–C · 766 Ų buried · 12 hydrogen bonds · protein-protein
- B–C · 454 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 5CQX · E. coli MazF mutant E24A in complex with MazE residues 68-82 form I · the same entry in another collection · chain A against A, TM-score 1.00
- P0AE70 · AlphaFold monomer V2.0 prediction for endoribonuclease toxin mazf (P0AE70) · a predicted model of the same protein · chain A against A, TM-score 0.88
- P0AE72 · AlphaFold monomer V2.0 prediction for antitoxin maze (P0AE72) · a predicted model of the same protein · chain C against A, TM-score 0.40
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AE70
- Every structure of UniProt P0AE72
- Elsewhere: RCSB PDB 5CQX · PDBe 5CQX · UniProt P0AE70 · UniProt P0AE72
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