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Crystal structure of yeast ENT5 N-terminal domain-native

Analyse Crystal structure of yeast ENT5 N-terminal domain-native in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CMY
Type: protein
Length: 284 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Epsin-5
UniProt: Q03769
Pockets: 1 · best druggability 0.62

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Epsin-5	protein	142	74% helix, 0% strand	Q03769
B	Epsin-5	protein	142	75% helix, 0% strand	Q03769

Ligands and binding sites

GOL · Glycerol · additive · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	536	0.62	0.74	46	empty

Interfaces

1 interface between chains.

A–B · 175 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5CMY · Crystal structure of yeast Ent5 N-terminal domain-native · the same entry in another collection · chain A against A, TM-score 1.00
Q03769 · AlphaFold monomer V2.0 prediction for epsin-5 (Q03769) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03769
Elsewhere: RCSB PDB 5CMY · PDBe 5CMY · UniProt Q03769

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