Research workbench
Anti-B7-H3 monoclonal antibody CH8H9 Fab fragment
Analyse Anti-B7-H3 monoclonal antibody CH8H9 Fab fragment in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CMA
- Type
- protein
- Length
- 426 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody CH8H9 Fab light chain; Antibody CH8H9 Fab heavy chain
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Antibody CH8H9 Fab light chain | protein | 213 | 6% helix, 48% strand | — |
| B | Antibody CH8H9 Fab heavy chain | protein | 213 | 6% helix, 51% strand | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 858 | 0.70 | 0.76 | 71 | empty |
| 2 | 124 | 0.37 | 0.73 | 26 | empty |
| 3 | 63 | 0.27 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 1723 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 5CMA · Anti-B7-H3 monoclonal antibody ch8H9 Fab fragment · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5CMA · PDBe 5CMA
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