Research workbench
Crystal structure of tissue factor in complex with humanized Fab D3H44
Analyse Crystal structure of tissue factor in complex with humanized Fab D3H44 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JPS
- Type
- protein
- Length
- 626 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin Fab D3H44, light chain; Immunoglobulin Fab D3H44, heavy chain; Tissue…
- UniProt
- P13726
- Pockets
- 5 · best druggability 0.64
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Immunoglobulin Fab D3H44, light chain | protein | 213 | 6% helix, 52% strand | — |
| H | Immunoglobulin Fab D3H44, heavy chain | protein | 213 | 7% helix, 54% strand | — |
| T | Tissue factor | protein | 200 | 8% helix, 49% strand | P13726 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 652 | 0.64 | 0.75 | 60 | empty |
| 2 | 106 | 0.43 | 0.78 | 27 | empty |
| 3 | 95 | 0.43 | 0.78 | 24 | empty |
| 4 | 102 | 0.37 | 0.75 | 22 | empty |
| 5 | 55 | 0.25 | 0.73 | 18 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1628 Ų buried · 13 hydrogen bonds · protein-protein
- H–T · 744 Ų buried · 16 hydrogen bonds · protein-protein
- L–T · 342 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13726
- Elsewhere: RCSB PDB 1JPS · PDBe 1JPS · UniProt P13726
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