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Crystal structure of conserpin with Z-mutation
Analyse Crystal structure of conserpin with Z-mutation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CE0
- Type
- protein
- Length
- 705 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Native conserpin with Z-variant (E342K)
- Pockets
- 7 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Native conserpin with Z-variant (E342K) | protein | 352 | 31% helix, 32% strand | — |
| B | Native conserpin with Z-variant (E342K) | protein | 353 | 31% helix, 33% strand | — |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 505 | 0.66 | 0.78 | 47 | empty |
| 2 | 187 | 0.64 | 0.84 | 34 | empty |
| 3 | 186 | 0.63 | 0.84 | 33 | empty |
| 4 | 98 | 0.43 | 0.78 | 24 | empty |
| 5 | 127 | 0.38 | 0.74 | 30 | empty |
Interfaces
1 interface between chains.
- A–B · 495 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5CE0 · Crystal structure of conserpin with Z-mutation · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 5CE0 · PDBe 5CE0
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