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Structure of leishmania nucleoside diphosphate kinase mutant P100S/DEL5-cterm

Analyse Structure of leishmania nucleoside diphosphate kinase mutant P100S/DEL5-cterm in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5CAA
Type: protein
Length: 275 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nucleoside diphosphate kinase
EC: 2.7.4.6
UniProt: Q9U1E1
Pockets: 3 · best druggability 0.48

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nucleoside diphosphate kinase (EC 2.7.4.6)	protein	137	45% helix, 18% strand	Q9U1E1
B	Nucleoside diphosphate kinase (EC 2.7.4.6)	protein	138	46% helix, 17% strand	Q9U1E1

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	192	0.48	0.75	28	empty
2	134	0.39	0.74	28	empty
3	81	0.32	0.74	14	empty

Interfaces

1 interface between chains.

A–B · 567 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

5CAA · Structure of Leishmania nucleoside diphosphate kinase mutant P100S/del5-Cterm · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9U1E1
Elsewhere: RCSB PDB 5CAA · PDBe 5CAA · UniProt Q9U1E1

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