Research workbench
Crystal structure of a complex of human CDK6 and a viral cyclin
Analyse Crystal structure of a complex of human CDK6 and a viral cyclin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JOW
- Type
- protein
- Length
- 520 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin homolog; Cell division protein kinase 6
- EC
- 2.7.1.-
- UniProt
- Q01043, Q00534
- Pockets
- 7 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cyclin homolog | protein | 243 | 63% helix, 1% strand | Q01043 |
| B | Cell division protein kinase 6 (EC 2.7.1.-) | protein | 277 | 34% helix, 12% strand | Q00534 |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 197 | 0.74 | 0.89 | 32 | empty |
| 2 | 177 | 0.56 | 0.80 | 23 | empty |
| 3 | 105 | 0.55 | 0.84 | 23 | empty |
| 4 | 195 | 0.54 | 0.79 | 38 | empty |
| 5 | 52 | 0.47 | 0.85 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 2062 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 1JOW · Crystal structure of a complex of human CDK6 and a viral cyclin · the same entry in another collection · chain A against A, TM-score 1.00
- Q00534 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 6 (Q00534) · a predicted model of the same protein · chain B against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01043
- Every structure of UniProt Q00534
- Elsewhere: RCSB PDB 1JOW · PDBe 1JOW · UniProt Q01043 · UniProt Q00534
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