PH domain of ASAP1 in complex with DIC4-PTDINS(4,5)P2

Structure

x-ray diffraction · 2 distinct chains · 24% helix, 40% strand (DSSP).

Ligands and binding sites

• PBU · (2R)-3-{[(R)-hydroxy{[(1r,2r,3s,4r,5r,6s)-2,3,6-trihydroxy-4,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dibutanoate · ligand · 3 copies · chains A, B
• CL · Chloride ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 186 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 5C79 · PH domain of ASAP1 in complex with diC4-PtdIns(4,5)P2 · the same entry in another collection · chain A against A, TM-score 1.00
• Q9QWY8 · AlphaFold monomer V2.0 prediction for arf-gap with SH3 domain, ank repeat and pH… · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9QWY8
• Elsewhere: RCSB PDB 5C79 · PDBe 5C79 · UniProt Q9QWY8