Research workbench
Constitutively active sin recombinase cataltyic domain - I100T/Q115R
Analyse Constitutively active sin recombinase cataltyic domain - I100T/Q115R in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5C34
- Type
- protein
- Length
- 239 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative transposon TN552 DNA-invertase BIN3
- UniProt
- P20384
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.48
Structure
x-ray diffraction · 2 distinct chains · 47% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Putative transposon TN552 DNA-invertase BIN3 | protein | 115 | 49% helix, 17% strand | P20384 |
| C | Putative transposon TN552 DNA-invertase BIN3 | protein | 124 | 46% helix, 17% strand | P20384 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 3 copies · chains B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 88 | 0.48 | 0.82 | 15 | empty |
| 2 | 86 | 0.45 | 0.80 | 17 | empty |
| 3 | 60 | 0.30 | 0.75 | 18 | empty |
| 4 | 50 | 0.27 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- B–C · 542 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified (engineered).
Compared structures
- 5C34 · Constitutively active Sin recombinase cataltyic domain - I100T/Q115R · the same entry in another collection · chain B against B, TM-score 1.00
- P20384 · AlphaFold monomer V2.0 prediction for putative transposon TN552 DNA- invertase BIN3… · a predicted model of the same protein · chain C against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P20384
- Elsewhere: RCSB PDB 5C34 · PDBe 5C34 · UniProt P20384
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.