Research workbench
The structure of oxidized rat cytochrome C at 1.13 ångströms resolution
Analyse The structure of oxidized rat cytochrome C at 1.13 ångströms resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5C0Z
- Type
- protein
- Length
- 416 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cytochrome C, somatic
- UniProt
- P62898
- Ligands
- HEC, FC6
- Pockets
- 5 · best druggability 0.83
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Cytochrome C, somatic | protein | 104 | 41% helix, 2% strand | P62898 |
Ligands and binding sites
- HEC · Heme C · ligand · 4 copies · chains A, D, B, C
- FC6 · Hexacyanoferrate(3-) · ligand · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 672 | 0.83 | 0.87 | 86 | HEC, FC6 |
| 2 | 652 | 0.82 | 0.87 | 90 | HEC, FC6 |
| 3 | 65 | 0.28 | 0.73 | 18 | empty |
| 4 | 56 | 0.27 | 0.74 | 18 | empty |
| 5 | 57 | 0.26 | 0.73 | 14 | empty |
Interfaces
4 interfaces between chains.
- A–D · 445 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 418 Ų buried · 1 hydrogen bond · protein-protein
- A–B · 223 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 193 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 cofactor (heme c attachment).
Compared structures
- 5C0Z · The structure of oxidized rat cytochrome c at 1.13 angstroms resolution · the same entry in another collection · chain D against D, TM-score 1.00
- P62898 · AlphaFold monomer V2.0 prediction for cytochrome C, somatic (P62898) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62898
- Elsewhere: RCSB PDB 5C0Z · PDBe 5C0Z · UniProt P62898
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