Research workbench
The crystal structure of polyglycilated 14-3-3 protein from giardia intestinalis
Analyse The crystal structure of polyglycilated 14-3-3 protein from giardia intestinalis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5BY9
- Type
- protein
- Length
- 937 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein
- UniProt
- Q2QBT8
- Pockets
- 13 · best druggability 0.59
Structure
x-ray diffraction · 4 distinct chains · 81% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein | protein | 236 | 80% helix, 0% strand | Q2QBT8 |
| B | 14-3-3 protein | protein | 235 | 81% helix, 0% strand | Q2QBT8 |
| C | 14-3-3 protein | protein | 232 | 81% helix, 0% strand | Q2QBT8 |
| D | 14-3-3 protein | protein | 234 | 82% helix, 0% strand | Q2QBT8 |
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 306 | 0.59 | 0.77 | 30 | empty |
| 2 | 338 | 0.57 | 0.76 | 28 | empty |
| 3 | 321 | 0.56 | 0.76 | 24 | empty |
| 4 | 297 | 0.55 | 0.76 | 30 | empty |
| 5 | 54 | 0.49 | 0.86 | 13 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1476 Ų buried · 6 hydrogen bonds · protein-protein
- A–B · 1365 Ų buried · 15 hydrogen bonds · protein-protein
- C–D · 1284 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 5BY9 · The crystal structure of polyglycilated 14-3-3 protein from Giardia intestinalis · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q2QBT8
- Elsewhere: RCSB PDB 5BY9 · PDBe 5BY9 · UniProt Q2QBT8
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