Research workbench
PMOB1-LATS1 complex
Analyse PMOB1-LATS1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5BRK
- Type
- protein
- Length
- 258 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mob kinase activator 1A; SERINE/THREONINE-protein kinase LATS1
- EC
- 2.7.11.1
- UniProt
- Q9H8S9, O95835
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 62% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mob kinase activator 1A | protein | 194 | 52% helix, 6% strand | Q9H8S9 |
| B | SERINE/THREONINE-protein kinase LATS1 (EC 2.7.11.1) | protein | 64 | 91% helix, 0% strand | O95835 |
Ligands and binding sites
- ZN · Zinc ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 341 | 0.67 | 0.81 | 32 | empty |
Interfaces
1 interface between chains.
- A–B · 1313 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 7 modified (engineered, phosphorylation).
Compared structures
- 5BRK · pMob1-Lats1 complex · the same entry in another collection · chain A against A, TM-score 1.00
- O95835 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase LATS1 (O95835) · a predicted model of the same protein · chain B against A, TM-score 0.89
- Q9H8S9 · AlphaFold monomer V2.0 prediction for mob kinase activator 1A (Q9H8S9) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H8S9
- Every structure of UniProt O95835
- Elsewhere: RCSB PDB 5BRK · PDBe 5BRK · UniProt Q9H8S9 · UniProt O95835
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.