Research workbench
Crystal structure of putative marr family transcriptional regulator hcar from acinetobacter sp. ADP complexed with 24MER DNA.
Analyse Crystal structure of putative marr family transcriptional regulator hcar from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5BMZ
- Type
- protein + DNA
- Length
- 648 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hcar protein; DNA (5'- D(P*GP*AP*AP*TP*AP*TP*CP*AP*GP*TP*TP*AP*AP*AP*CP*TP*GP*AP*TP*AP*TP*…
- UniProt
- Q7X0D9
- Pockets
- 11 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 65% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Hcar protein | protein | 139 | 65% helix, 9% strand | Q7X0D9 |
| E, F, G, H | DNA (5'- D(P*GP*AP*AP*TP*AP*TP*CP*AP*GP*TP*TP*AP*AP*AP*CP*TP*GP*AP*TP*AP*TP*TP *C)-3') | dna | 23 | — | — |
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1118 | 0.83 | 0.84 | 79 | empty |
| 2 | 1095 | 0.82 | 0.83 | 82 | empty |
| 3 | 317 | 0.60 | 0.78 | 37 | empty |
| 4 | 191 | 0.51 | 0.78 | 24 | empty |
| 5 | 71 | 0.40 | 0.79 | 13 | empty |
Interfaces
14 interfaces between chains.
- C–D · 2504 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 2483 Ų buried · 19 hydrogen bonds · protein-protein
- E–F · 976 Ų buried · 88 hydrogen bonds · nucleic-nucleic
- G–H · 975 Ų buried · 89 hydrogen bonds · nucleic-nucleic
- D–G · 536 Ų buried · 8 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 5BMZ · Crystal Structure of Putative MarR Family Transcriptional Regulator HcaR from… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7X0D9
- Elsewhere: RCSB PDB 5BMZ · PDBe 5BMZ · UniProt Q7X0D9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.