Research workbench
Inward-facing conformation of ABC heme importer bhuuv in complex with periplasmic heme binding protein bhut from burkholderia cenocepacia
Analyse Inward-facing conformation of ABC heme importer bhuuv in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5B58
- Type
- protein
- Length
- 1,438 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative hemin ABC transport system, membrane protein; Hemin import ATP-binding protein…
- EC
- 3.6.3.-
- UniProt
- B4EKB4, B4EKB5, B4EKB3
- Pockets
- 16 · best druggability 0.84
Structure
x-ray diffraction · 4 distinct chains · 50% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Putative hemin ABC transport system, membrane protein | protein | 331 | 73% helix, 0% strand | B4EKB4 |
| C | Hemin import ATP-binding protein hmuv (EC 3.6.3.-) | protein | 258 | 37% helix, 28% strand | B4EKB5 |
| D | Hemin import ATP-binding protein hmuv (EC 3.6.3.-) | protein | 253 | 38% helix, 26% strand | B4EKB5 |
| T | Putative hemin transport system, substrate-binding protein | protein | 265 | 45% helix, 19% strand | B4EKB3 |
Pockets
16 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1148 | 0.84 | 0.85 | 122 | empty |
| 2 | 545 | 0.76 | 0.83 | 88 | empty |
| 3 | 1036 | 0.75 | 0.78 | 71 | empty |
| 4 | 489 | 0.65 | 0.77 | 55 | empty |
| 5 | 58 | 0.64 | 0.93 | 19 | empty |
Interfaces
7 interfaces between chains.
- A–B · 1771 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 1342 Ų buried · 7 hydrogen bonds · protein-protein
- B–T · 1245 Ų buried · 8 hydrogen bonds · protein-protein
- B–D · 1239 Ų buried · 9 hydrogen bonds · protein-protein
- C–D · 992 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5B58 · Inward-facing conformation of ABC heme importer BhuUV in complex with periplasmic heme… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B4EKB4
- Every structure of UniProt B4EKB5
- Every structure of UniProt B4EKB3
- Elsewhere: RCSB PDB 5B58 · PDBe 5B58 · UniProt B4EKB4 · UniProt B4EKB5 · UniProt B4EKB3
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