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Polyketide cyclase oac from cannabis sativa

Analyse Polyketide cyclase oac from cannabis sativa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5B08
Type: protein
Length: 204 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Olivetolic acid cyclase
EC: 4.4.1.26
UniProt: I6WU39
Pockets: 3 · best druggability 0.56

Structure

x-ray diffraction · 2 distinct chains · 30% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Olivetolic acid cyclase (EC 4.4.1.26)	protein	100	41% helix, 31% strand	I6WU39
B	Olivetolic acid cyclase (EC 4.4.1.26)	protein	104	20% helix, 35% strand	I6WU39

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	89	0.56	0.85	17	empty
2	87	0.33	0.74	16	empty
3	74	0.30	0.73	17	empty

Interfaces

1 interface between chains.

A–B · 1326 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

5B08 · Polyketide cyclase OAC from Cannabis sativa · the same entry in another collection · chain A against A, TM-score 1.00
I6WU39 · AlphaFold monomer V2.0 prediction for olivetolic acid cyclase (I6WU39) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt I6WU39
Elsewhere: RCSB PDB 5B08 · PDBe 5B08 · UniProt I6WU39

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