Research workbench
Crystal structure of bacillus stearothermophilus farnesyl pyrophosphate synthase
Analyse Crystal structure of bacillus stearothermophilus farnesyl pyrophosphate synthase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AYP
- Type
- protein
- Length
- 522 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Farnesyl diphosphate synthase
- EC
- 2.5.1.10
- UniProt
- Q08291
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 2 distinct chains · 76% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Farnesyl diphosphate synthase (EC 2.5.1.10) | protein | 258 | 75% helix, 2% strand | Q08291 |
| B | Farnesyl diphosphate synthase (EC 2.5.1.10) | protein | 264 | 77% helix, 0% strand | Q08291 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 363 | 0.60 | 0.77 | 43 | empty |
| 2 | 324 | 0.59 | 0.78 | 42 | empty |
| 3 | 94 | 0.38 | 0.76 | 10 | empty |
| 4 | 102 | 0.38 | 0.75 | 10 | empty |
| 5 | 71 | 0.36 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 2048 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 5AYP · Crystal structure of Bacillus stearothermophilus Farnesyl pyrophosphate synthase · the same entry in another collection · chain A against A, TM-score 1.00
- Q08291 · AlphaFold monomer V2.0 prediction for farnesyl diphosphate synthase (Q08291) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q08291
- Elsewhere: RCSB PDB 5AYP · PDBe 5AYP · UniProt Q08291
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