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Crystal structure of the reduced form of homoserine dehydrogenase from sulfolobus tokodaii.

Analyse Crystal structure of the reduced form of homoserine dehydrogenase from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5AVO
Type: protein
Length: 599 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Homoserine dehydrogenase
EC: 1.1.1.3
UniProt: F9VNG5
Pockets: 4 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Homoserine dehydrogenase (EC 1.1.1.3)	protein	299	38% helix, 22% strand	F9VNG5
B	Homoserine dehydrogenase (EC 1.1.1.3)	protein	300	38% helix, 22% strand	F9VNG5

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	384	0.59	0.76	34	empty
2	235	0.54	0.77	33	empty
3	248	0.51	0.75	32	empty
4	240	0.50	0.75	27	empty

Interfaces

1 interface between chains.

A–B · 1537 Å² buried · 30 hydrogen bonds · protein-protein

Compared structures

5AVO · Crystal structure of the reduced form of homoserine dehydrogenase from Sulfolobus… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F9VNG5
Elsewhere: RCSB PDB 5AVO · PDBe 5AVO · UniProt F9VNG5

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